RIV/61989592:15310/13:33147716 - A conceptually new treatment approach for relapsed glioblastoma: coordinated undermining of survival paths with nine repurposed drugs (CUSP9) by the International Initiative for Accelerated Improvement of Glioblastoma Care
Údaje o výsledku
Identifikační kód:RIV/61989592:15310/13:33147716 Název v původním jazyce:A conceptually new treatment approach for relapsed glioblastoma: coordinated undermining of survival paths with nine repurposed drugs (CUSP9) by the International Initiative for Accelerated Improvement of Glioblastoma Care Název česky: Druh:J - Článek v odborném periodiku Jazyk:eng - angličtina Obor:FR - Farmakologie a lékárnická chemie Rok uplatnění:2013 Kód důvěrnosti:S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů Počet tvůrců:28 Počet domácích tvůrců:1 Tvůrce:Kast, Richard E Tvůrce: Boockvar, John A Tvůrce: Brüning, Ansgar Tvůrce: Cappello, Francesco Tvůrce: Chang, Wen-Wei Tvůrce: Cvek, Boris Tvůrce: Dou, Q Ping Tvůrce: Duenas-Gonzalez, Alfonso Tvůrce: Efferth, Thomas Tvůrce: Focosi, Daniele Tvůrce: Ghaffari, Seyed H Tvůrce: Karpel-Massler, Georg Tvůrce: Ketola, Kirsi Tvůrce: Khoshnevisan, Alireza Tvůrce: Keizman, Daniel Tvůrce: Magné, Nicolas Tvůrce: Marosi, Christine Tvůrce: Mcdonald, Kerrie Tvůrce: Munoz, Miguel Tvůrce: Paranjpe, Ameya Tvůrce: Pourgholami, Mohammad H Tvůrce: Sardi, Iacopo Tvůrce: Sella, Avishay Tvůrce: Srivenugopal, Kalkunte S Tvůrce: Tuccori, Marco Tvůrce: Wang, Weiguang Tvůrce: Wirtz, Christian R Tvůrce: Halatsch, Marc-Eric
Údaje blíže specifikující výsledek
Popis v původním jazyce:To improve prognosis in recurrent glioblastoma we developed a treatment protocol based on a combination of drugs not traditionally thought of as cytotoxic chemotherapy agents but that have a robust history of being well-tolerated and are already marketed and used for other non-cancer indications. Focus was on adding drugs which met these criteria: a) were pharmacologically well characterized, b) had low likelihood of adding to patient side effect burden, c) had evidence for interfering with a recognized, well-characterized growth promoting element of glioblastoma, and d) were coordinated, as an ensemble had reasonable likelihood of concerted activity against key biological features of glioblastoma growth. We found nine drugs meeting these criteria and propose adding them to continuous low dose temozolomide, a currently accepted treatment for relapsed glioblastoma, in patients with recurrent disease after primary treatment with the Stupp Protocol. The nine adjuvant drug regimen, Coordinated Undermining of Survival Paths, CUSP9, then are aprepitant, artesunate, auranofin, captopril, copper gluconate, disulfiram, ketoconazole, nelfinavir, sertraline, to be added to continuous low dose temozolomide. We discuss each drug in turn and the specific rationale for use- how each drug is expected to retard glioblastoma growth and undermine glioblastoma's compensatory mechanisms engaged during temozolomide treatment. The risks of pharmacological interactions and why we believe this drug mix will increase both quality of life and overall survival are reviewed. Popis česky: Klíčová slova: Název periodka:Oncotarget Rozsah stran: ISSN:1949-2553 Svazek periodika:4 Číslo periodika v rámci uvedeného svazku:4 Stát vydavatele periodika:US - Spojené státy americké Počet stran výsledku:29 DOI:
Údaje o tomto záznamu o výsledku
Předkladatel:Univerzita Palackého v Olomouci / Přírodovědecká fakulta (IČO: 61989592) Dodavatel:MSM Rok sběru:2014 Systémové označení dodávky dat:RIV14-MSM-15310___/01:1 Kontrolní kód:[5C43D90CB497]
